SharePoint Online/2019/2016/2013/2010/2007

Delete all files from the below locations. %USERPROFILE%\AppData\Local\Microsoft\WebsiteCache %APPDATA%\Microsoft\Web Server Extensions\Cache The below location go to manually:  %APPDATA%\Roaming\Microsoft\SharePoint Designer\ProxyAssemblyCache

On a SharePoint 2010 development server running Windows Server 2008 R2, I had to uninstall some assemblies in the GAC and keep getting access denied, when trying to delete them. So, looking for at a way to do this, I had to change a Local Security Policy, in order to allow them to be deleted: * Open Local Security Policy MMC * Goto Security Settings -> Local Policies -> Security Options * Locate “User Account Control: Run all administrators in Admin Approval” and change the setting from Enabled to Disabled * Reboot and now the assemblies can be deleted IMPORTANT! Never ever do this on a production system, and always turn it back on afterwards.